LeBron James' First Game-Worn Lakers No. 6 Jersey Hits Auction

LeBron James' first-ever #6 Lakers jersey -- which he wore on the opening night of the 2021-22 NBA season -- is hitting the auction block ... and could sell for a ton of dough, TMZ Sports has learned.

A rep with SCP Auctions tells us the gold Nike "Icon" Edition jersey James sported against the Golden State Warriors on October 19, 2021, is up for grabs ... and it's a big deal, considering it's the first time he rocked #6 for L.A., instead of his Cleveland-era #23.

The bottom left corner of the piece of history shows LeBron's jersey size (54) and the date of the game, 10-19-21, handwritten on the tag.

The jersey has gone through several layers of authentication -- it was entered into the NBA and MeiGray Game-Worn Jersey Authentication Program -- and was photo matched to the 1st and 2nd half of the contest against the Warriors.

Remember, James switched from #23 to #6 in June 2021 ... just four months before the NBA season started. LeBron previously wore the #6 when he was with the Miami Heat for four seasons (2010-2014).

"It's always been a part of me, to be honest," James said when asked about the switch. "Six has a lot of meaning to me, from my family and numbers and things of that nature to what I believe in and things of that sort, but my mentality doesn’t change."

King James finished the night against the Warriors with a game-high 34 points to go along with 11 rebounds and five assists -- but the Dubs spoiled LeBron's night, defeating the Lakers, 121-114.

The auction ends on February 4. Good luck, bidders!